国晋菘  副研究员  

研究方向:

电子邮件:guojs@sibet.ac.cn

电       话:0512-69588135

通讯地址:

简       历:

国晋菘,博士,副研究员。2012年在兰州大学获得口腔临床医学硕士学位,2018年于北京大学获生物医学工程博士学位,具有临床医学和生物医学工程跨学科研究背景。2019年加盟中国科学院苏州医工所,历任助理研究员、副研究员。致力于发展新型物理治疗技术及其生物医学效应基础研究,研制和产业化相应的医疗器械设备。先后承担国家重点研发计划、国家自然基金、江苏省双创博士等多项人才和科研项目。申请国内外发明专利10余项(含国际PCT专利1项),已授权发明专利3项。在SCI 收录期刊上发表论文22篇,其中第一/通讯作者论文10篇。

获奖及荣誉:

2019年,江苏省双创博士

2021年,甘肃省医学科技奖一等奖

社会任职:

研究方向:

高压放电与等离子体技术在生物医学方面的应用研究

光电热等多物理因子的生物学效应与机理研究

生物组织的物理特性研究

一氧化氮信号通路分子靶点和机制的研究

承担项目情况:

1.       国家重点研发计划课题项目,2020YFC0122301,高低温复合式肿瘤多模态治疗设备(康博刀)研发,202010月至202309月,经费154万,负责人;

2.       江苏省双创博士人才项目,Y1188006038201910月至202209月,经费15万,负责人;

3.       国家自然科学基金委员会, 面上项目, 81772334, 纳秒脉冲电场调控间充质干细胞软骨分化的机理探究, 201801 202112月,经费55元,参与;

4.       国家重点研发计划课题项目,2020YFC0122304,高低温复合物理免疫治疗实验研究,202010月至202309月,经费80万,参与;

代表论著:

[1] Sun K., Lu X., Yin C., Guo J*. (2022). In vitro antitumor activity of nano-pulse stimulation on human anaplastic thyroid cancer cells through nitric oxide-dependent mechanisms. Bioelectrochemistry, 108093.

[2] Zhu, C., Chen, C., Guo, J., Wang, Q., Rao, J., Li, H., ... & Zhuang, J. Cold atmospheric plasma inhibits vesicle transport of human osteosarcoma cells visualized by super‐resolution fluorescence microscopy. Plasma Processes and Polymers, e2100210.

[3] Gu, Y., Zhang, L., Yang, H., Zhuang, J., Sun, Z., Guo, J*., & Guan, M. (2021). Nanosecond pulsed electric fields impair viability and mucin expression in mucinous colorectal carcinoma cell. Bioelectrochemistry, 141, 107844.

[4] Zhang, L., Shi, F., Guo, J., Wang, Q., Kolb, J. F., Wang, W., ... & Zhuang, J. (2021). Impedimetric characterization of normal and cancer cell responses after nano-pulse stimulation. Journal of Physics D: Applied Physics, 54(18), 185401.

[5] 廖非, 杨晨, 曹莉, 钱春燕, 庄杰, & 国晋菘. (2021). 大气压低温等离子体对大鼠急性化脓性感染伤口愈合的影响. 中国皮肤性病学杂志, 35(8), 6.

[6] Ning, T., Guo, J., Zhang, K., Li, K., Zhang, J., Yang, Z., & Ge, Z. (2019). Nanosecond pulsed electric fields enhanced chondrogenic potential of mesenchymal stem cells via JNK/CREB-STAT3 signaling pathway. Stem cell research & therapy, 10(1), 1-12.

[7] Liu, J., Lu, Q., Liang, R., Guo, J., Wang, K., Dong, F., ... & Fang, J. (2019). Communicating with mouse oocytes via regulating calcium oscillation patterns by nanosecond pulsed electric fields. Physical Review Applied, 11(2), 024001.

[8] Hongzhuan, Z., Ying, T., Xia, S., Jinsong, G., Zhenhua, Z., Beiyu, J., ... & Jing, F. (2020). Preparation of the inactivated Newcastle disease vaccine by plasma activated water and evaluation of its protection efficacy. Applied microbiology and biotechnology, 104(1), 107-117.

[9] Guo, J#., Dong, F., Ding, L., Wang, K., Zhang, J., & Fang, J. (2018). A novel drug-free strategy of nano-pulse stimulation sequence (NPSS) in oral cancer therapy: In vitro and in vivo study. Bioelectrochemistry, 123, 26-33.

[10] Guo, J#., Dang, J., Wang, K., Zhang, J., & Fang, J. (2018). Effects of nanosecond pulsed electric fields (nsPEFs) on the human fungal pathogen Candida albicans: an in vitro study. Journal of Physics D: Applied Physics, 51(18), 185402.

[11] Dong, F., Zhang, J., Wang, K., Liu, Z., Guo, J., & Zhang, J. (2019). Cold plasma gas loaded microbubbles as a novel ultrasound contrast agent. Nanoscale, 11(3), 1123-1130.

[12] Zhang, Y., Dong, F., Liu, Z., Guo, J., Zhang, J., & Fang, J. (2018). Nanosecond pulsed electric fields promoting the proliferation of porcine iliac endothelial cells: An in vitro study. PloS one, 13(5), e0196688.

[13] Tian, Y#., Guo, J.#, Wu, D., Wang, K., Zhang, J., & Fang, J. (2017). The potential regulatory effect of nitric oxide in plasma activated water on cell growth of Saccharomyces cerevisiae. Journal of Applied Physics, 122(12), 123302.

[14] Yang, Y., Guo, J., Zhou, X., Liu, Z., Wang, C., Wang, K., ... & Wang, Z. (2018). A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An in vitro study. Dental Materials Journal, 37(1), 157-166.

[15] Guo, J.#, Wang, Y., Wang, J., Zhang, J., & Fang, J. (2017). Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs). Bioelectrochemistry, 113, 35-41.

[16] Guo, J.#, Ma, R., Su, B., Li, Y., Zhang, J., & Fang, J. (2016). Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). Scientific Reports, 6(1), 1-10.

[17] Su, B., Guo, J., Nian, W., Feng, H., Wang, K., Zhang, J., & Fang, J. (2015). Early growth effects of nanosecond pulsed electric field (nsPEFs) exposure on Haloxylon ammodendron. Plasma Processes and Polymers, 12(4), 372-379.

[18] Wu, S., Guo, J., Wei, W., Zhang, J., Fang, J., & Beebe, S. J. (2014). Enhanced breast cancer therapy with nsPEFs and low concentrations of gemcitabine. Cancer Cell International, 14(1), 1-12.

[19] Ma, R., Feng, H., Guo, J., Liang, Y., Zhang, Q., Tian, Y., ... & Fang, J. (2014). An efficient and specific protection of non‐thermal plasma‐induced live yeast cell derivative (LYCD) for cells against plasma damage. Plasma Processes and Polymers, 11(9), 822-832.

[20] Zhang, K., Guo, J., Ge, Z., & Zhang, J. (2014). Nanosecond pulsed electric fields (nsPEFs) regulate phenotypes of chondrocytes through Wnt/β-catenin signaling pathway. Scientific reports, 4(1), 1-8.

[21] Wu, S., Wang, Y., Guo, J., Chen, Q., Zhang, J., & Fang, J. (2014). Nanosecond pulsed electric fields as a novel drug free therapy for breast cancer: an in vivo study. Cancer letters, 343(2), 268-274.

[22] Qi, W., Guo, J., Wu, S., Su, B., Zhang, L., Pan, J., & Zhang, J. (2014). Synergistic effect of nanosecond pulsed electric field combined with low-dose of pingyangmycin on salivary adenoid cystic carcinoma. Oncology Reports, 31(5), 2220-2228.

[23] Jing, W.#, Guo, J. #, Shan, W., Feng, H., Sun, S., & Jie, P., et al. (2012). Synergistic effects of nanosecond pulsed electric fields combined with low concentration of gemcitabine on human oral squamous cell carcinoma in vitro. Plos One, 7.

[24] 国晋菘#, 潘洁, 张茜, 吴杉, 梁永栋, & 王静. (2012). 大气压低温等离子体的活性氧成分分析及其杀菌效应研究. 北京大学学报(自然科学版)(4), 533-537.

[25] 冯蕊, 国晋菘, 何津祥, 杨小慧, 孙科, & 王静. (2011). 甘氨双唑钠对tca-8113细胞体外放射增敏及黏附作用的影响. 中国癌症杂志, 021(001), 17-21.

[26] 冯蕊, 何津祥, 国晋菘, 孙科, 杨小慧, & 王静. (2011). 吴茱萸碱联合射线对舌鳞状细胞癌tca-8113细胞增殖,黏附和迁移的影响. 肿瘤, 31(5), 7.

已经授权发明专利:

[1] 一种血管支架的快速内皮化设备及其方法,201710655499.3

[2] 一种卵母细胞激活的物理方法及其受精潜能的评价指标,201710692030.7

[3] 一种提高阿维菌素产量的方法,201510441003.3