宋一之  研究员  



电       话:


简       历:

宋一之,研究员,博导,苏州市姑苏领军人才获得者。2001年进入清华大学环境工程系学习,先后获得工学学士、博士学位。2011-2018年期间先后在清华大学、英国谢菲尔德大学和英国牛津大学任博士后研究员。2018年参与创办以开发临床微生物诊断工具为目标的医疗器械企业。2020年加入中国科学院苏州生物医学工程技术研究所。长期以来主要从事病原微生物和单细胞分析等领域的研究,在微生物单细胞表型的拉曼光谱学、单细胞基因组扩增、临床耐药菌耐药特征和合成生物学等领域取得了一系列重要的原创性成果。在Analytical Chemistry, Nucleic Acids Research, Environmental Science & Technology, Current Opinion in Chemical BiologyMicrobial Biotechnology等期刊发表SCI收录论文和英文专著章节48篇。国家发明专利授权5项,实用新型专利授权3项。作为项目负责人或子课题项目负责人承担国家自然基金委面上、科技部重点研发计划、中科院装备研制项目、863计划课题、科技部基础工作专项课题和博士后基金课题。多项研究成果已被转化,受到市场一致认可。一项成果形成国家行业标准,成绩较为突出。







1)      病原感染精准诊断技术

2)      细菌耐药机制研究

3)      新型拉曼光谱技术、设备开发与其生物医学应用



1.         Jin N, Yang K, Li J, Song Y, Ding A, Sun Y, Li G & Zhang D. (2023). Toxicity Characterization of Environment-Related Pollutants Using a Biospectroscopy–Bioreporter-Coupling Approach: Potential for Real-World Toxicity Determination and Source Apportionment of Multiple Pollutants. Analytical Chemistry.

2.         Wang J, Meng S, Lin K, Yi X, Song Y, Xu X, He N, Zhang Z, Hu H, Qie X, Zhang D, Tang Y, Huang W, He J* & Song, Y* (2023). Leveraging single-cell Raman spectroscopy and single-cell sorting for the detection and identification of yeast infections. Analytica Chimica Acta1239, 340658.

3.         Liu M, Mu J, Gong W, Zhang K, Yuan M, Song Y, Li B, Jin N, Zhang W & Zhang, D. (2022). In Vitro Diagnosis and Visualization of Cerebral Ischemia/Reperfusion Injury in Rats and Protective Effects of Ferulic Acid by Raman Biospectroscopy and Machine Learning. ACS Chemical Neuroscience.

4.         Wang P, Song Y, Mei Q, Dong W-F, Li L. Sliver nanoparticles@ carbon dots for synergistic antibacterial activity. Applied Surface Science 2022, 600: 154125.

5.         Bai H, Meng S, Xiong C, Liu Z, Shi W, Ren Q, Xia W, Zhao W, Jian G, Song Y, Ni C & Li Z. Preoperative CECT-based Radiomic Signature for Predicting the Response of Transarterial Chemoembolization (TACE) Therapy in Hepatocellular Carcinoma. CardioVascular and Interventional Radiology 2022, 45(10): 1524-1533.

6.         Hu H, Wang J, Yi X, Lin K, Meng S, Zhang X, Jiang C, Tang Y, Wang M, He J*, Xu X* & Song Y*. Stain-free Gram staining classification of pathogens via single-cell Raman spectroscopy combined with machine learning[J]. Analytical Methods, 2022, 14(40): 4014-4020.

7.         Qie X, Zan M, Gui P, Chen H, Wang J, Lin K, Mei Q, Ge M, Zhang Z, Tang Y, Dong W-F* and Song Y* (2022). "Design, Synthesis, and Application of Carbon Dots With Synergistic Antibacterial Activity." Frontiers in Bioengineering and Biotechnology, 2022, 10.

8.         Yuan S., Chen Y, Lin K, Zou L, Lu X, He N, Liu R, Zhang S, Shen D, Song Z, Tong C, Song Y*, Zhang W, Chen L and Sun G (2022). "Single Cell Raman Spectroscopy Deuterium Isotope Probing for Rapid Antimicrobial Susceptibility Test of Elizabethkingia spp." Frontiers in Microbiology, 2022. 13.

9.         Gao R, Meng M, Zhou X, Yu M, Li Z, Li J, Wang X, Song Y*, Wang H*, He J*. TRPV1, a novel biomarker associated with lung cancer via excluding immune infiltration". Medcomm, 2022. 3(2): p. e139.

10.     Sun J, Zhang Z*, Li H, Yin H*, Hao P, Dai X, Jiang K, Liu C, Zhang T, Yin J, Song Y*, Zhou W, Gao J. Ultrasensitive SERS Analysis of Liquid and Gaseous Putrescine and Cadaverine by a 3D-Rosettelike Nanostructure-Decorated Flexible Porous Substrate. Anal Chem 2022, 94(13): 5273-5283.

11.     Jin N, Song Y, Ma R, Li J, Li G, Zhang D. Characterization and identification of microplastics using Raman spectroscopy coupled with multivariate analysis. Anal Chim Acta 2022, 1197: 339519.

12.     Yuan S, Chen Y, Song Y, Zou L, Lin K, Lu X, Liu R, Zhang S, Shen D, Song Z, Tang C, Chen L & Sun, G. (2021). Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp. bioRxiv, 2021-06.

13.     He J*, Gao R, Meng M, Yu M, Liu C, Li J, Song Y*, Wang H*. Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma. Int J Env Res Pub He 2021, 18(21): 11038.

14.     Wang J, Lin K, Hu H, Qie X, Huang WE, Cui Z, Gong Y, Song Y*. In Vitro Anticancer Drug Sensitivity Sensing through Single-Cell Raman Spectroscopy. Biosensor 2021, 11(8): 286.

15.     Yi X, Song Y, Xu X, et al. Development of a fast Raman-assisted antibiotic susceptibility test (FRAST) for the antibiotic resistance analysis of clinical urine and blood samples[J]. Analytical Chemistry, 2021, 93(12): 5098-5106.

16.     Chen J, Lim B, Steel H, Song Y.; Ji M.; Huang, W. Redesign of ultrasensitive and robust RecA gene circuit to sense DNA damage. Microbial Biotechnology, 2021

17.     Jiang B, Song Y, Liu Z, Huang WE, Li G, Deng S, Xing Y, Zhang D. Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination. Critical Reviews in Environmental Science and Technology 2020: 1-51.

18.     Song Y, et al. Overproduction of proteorhodopsin enhances long-term viability of Escherichia coli. Applied and environmental microbiology. 2020. 86(1) 02087-19

19.     Song Y, Cartron M, Jackson P, Davison P, Dickman M, Zhu D, ... & Hunter C. (2019). Proteorhodopsin overproduction enhances the long-term viability of Escherichia coli. Applied and Environmental Microbiology86(1), e02087-19.

20.     Jiang B, Zhang N, Xing Y, Lian L, Chen Y, Zhang D, ... & Song Y. (2019). Microbial degradation of organophosphorus pesticides: novel degraders, kinetics, functional genes, and genotoxicity assessment. Environmental Science and Pollution Research26, 21668-21681.

21.     Song Y, Rampley C, Chen X, Du F, Thompson I, & Huang W. (2019). Application of Bacterial Whole-Cell Biosensors in Health. In G. Thouand (Ed.), Handbook of Cell Biosensors (pp. 1-17). Cham: Springer International Publishing.

22.     Zhang Q, Song Y, et al. Monitoring Cr toxicity and remediation process – combining a whole-cell bioreporter and Cr isotope techniques, Water Research, 2019. 153:295-303

23.     Liang B, Gao Y, Xu J, Song Y, Xuan L, Shi T, Chen Z. Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 2019. 111(4), 753-762.e751.

24.     Jing, X, Gou H, Gong Y, Su X, Xu L, Ji Y, Song Y, Thompson, L Xu J and Huang W Raman-activated cell sorting and metagenomic sequencing revealing carbon-fixing bacteria in the ocean. Environ Microbiol. 2018( doi: 10.1111/1462-2920.14268.)

25.     Cui Z, Luan X, Jiang H, Li Q, Xu G, Sun C, Zheng L, Song Y, Davison P and Huang W, Application of a bacterial whole cell biosensor for the rapid detection of cytotoxicity in heavy metal contaminated seawater. Chemosphere 2018. 200: 322-329.

26.     Yuan X, Song Y, Song Y, et al., Effect of laser irradiation on cell function and its implications in Raman spectroscopy. Applied and Environmental Microbiology, 2018.(doi:10.1128/AEM.02508-17)

27.     Song Y., Kaster A, Vollmers J, Song Y, Davison P, Frentrup M, ... & Huang W. (2017). Singlecell genomics based on Raman sorting reveals novel carotenoidcontaining bacteria in the Red Sea. Microbial Biotechnology10(1), 125-137.

28.     Xu J, Zhu D, Ibrahim A, Allen C, Gibson C, Fowler P, Song Y & Huang W. (2017). Raman deuterium isotope probing reveals microbial metabolism at the single-cell level. Analytical chemistry, 89(24), 13305-13312.

29.     Song Y, Kaster AK, Vollmers J, Song Y, Davison PA, Frentrup M, et al. Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microb Biotechnol. 2017;10(1):125-37

30.     Song Y, et al., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Scientific Reports, 2017. 7(1): p. 16648

31.     Xu J., Zhu D., Ibrahim D., Allen R., Gibson M., Fowler W., Song Y., et al. Raman Deuterium Isotope Probing Reveals Microbial Metabolism at the Single-Cell Level. Analytical Chemistry, 2017. 89(24): p. 13305-13312

32.     Zhang P, Song Y, Thompson I, Ma B, Xu J & Huang W. (2016). Single-Cell Biotechnology for Uncultured Microorganisms. Hydrocarbon and Lipid Microbiology Protocols: Single-Cell and Single-Molecule Methods, 119-131.

33.     Wang Y, Song Y, Thompson I, Xu J, & Huang W. (2016). Single-cell metabolomics. Hydrocarbon and Lipid Microbiology Protocols: Single-Cell and Single-Molecule Methods, 77-90.

34.     Wang Y, Song Y, Tao Y, Muhamadali H, Goodacre R, Zhou N-Y, Preston GM, Xu J, Huang WE. 2016. Reverse and Multiple Stable Isotope Probing to Study Bacterial Metabolism and Interactions at the Single Cell Level. Analytical Chemistry 88:9443-9450

35.     Song Y, Yin H, and Huang W, Raman activated cell sorting. Current Opinion in Chemical Biology, 2016. 33: 1-8

36.     Jiang B, Zhu D, Song Y, Zhang D, Liu Z, Zhang X, ... & Li G. (2015). Use of a whole-cell bioreporter, Acinetobacter baylyi, to estimate the genotoxicity and bioavailability of chromium (VI)-contaminated soils. Biotechnology letters37, 343-348.

37.     Jiang B, Song Y, Zhang D, Huang W, Zhang X, & Li G. (2015). The influence of carbon sources on the expression of the recA gene and genotoxicity detection by an Acinetobacter bioreporter. Environmental Science: Processes & Impacts17(4), 835-843.

38.     Huang W, Song Y, & Xu J. (2015). Single cell biotechnology to shed a light on biological ‘dark matter’in nature. Microbial biotechnology8(1), 15.

39.     Huang W, Song Y, & Xu J. (2015). Study of uncultured bacteria. Microbial Biotechnology, (1), 15-16.

40.     Song Y, et al., A whole-cell bioreporter approach for the genotoxicity assessment of bioavailability of toxic compounds in contaminated soil in China. Environ Pollut, 2014. 195: 178-84

41.     Li C, Zhang D, Song Y, Jiang B, Li G, & Huang W. (2013). Whole cell bioreporter for the estimation of oil contamination. Environmental Engineering & Management Journal (EEMJ)12(7).

42.     Zhong Y, Wang J, Song Y, Liang Y, & Li G. (2012). Microbial community and functional genes in the rhizosphere of alfalfa in crude oil-contaminated soil. Frontiers of Environmental Science & Engineering6, 797-805.

43.     Song Y. (2012). Zhang, 4 Guanghe Li1, b and Wei E. Huang2, d. Biosensors and Environmental Health, 127.

44.     Song Y, Zhang D, Karen P, et al. Bacterial Whole-Cell Biosensors in Environmental Health // Victor R. Preedy. Biosensors and Environmental Health. CRC Press: Boca Raton, 2012

45.     Song Y, Li G, etc., Optimization of Bacterial Whole Cell Bioreporters for Toxicity Assay of Environmental Samples, Environmental Science & Technology, 2009. 43(20):7931-7938

46.     Song Y, Hahn T, etc., Ultrasound-mediated DNA transfer for bacteria, Nucleic Acids Research, 2007. 35(19):e129

47.     Meng M, Gao R, Liu Z, Song Y, Du S, & He J. Ginsenosides, potential TMPRSS2 inhibitors, a trade-off between the anti-PD-1 Immunotherapy modulators and treatment of COVID-19 infection of LUAD patients. Frontiers in Pharmacology14, 384.