马勇  研究员  

研究方向:

电子邮件:mayong@sibet.ac.cn

电       话:0512-69588328

通讯地址:苏州高新区科灵路88号

简       历:

  核酸检测技术中心副主任,博士生导师。本科毕业于北京大学生物化学和分子生物学专业,博士毕业于美国约翰霍普金斯大学医学院(Johns Hopkins University School of Medicine)并留校从事多年博士后研究。有十余年生物技术领域的研发经验(担任美国Merck制药公司高级生物学家和Biochain项目负责人)。在世界顶级的学术刊物《自然》(Nature)和《细胞》(Cell)上发表四篇论文。有扎实的生物化学、分子生物学,细胞生物学和遗传学科研背景,在DNARNA和蛋白质方面具有深厚的实践经验,包括与癌症相关的信号传导途径,RNA干扰,功能性基因组学,细胞检测方法开发,活体和体外药物靶标的鉴定和验证,高通量筛选试验和自动化操作,以及开发体外分子诊断技术的专业知识和经验。 

获奖及荣誉:

社会任职:

研究方向:

癌症早期筛查,分子诊断,精准医疗

承担项目情况:

代表论著:

  Publication 

  1.       Y. Ma, A. Creanga, L. Lum, and P. A. Beachy. (2006)Prevalence of Off-Target Effects in Drosophila RNA Interference Screens. Nature,.443, 359-363. 

  2.       Y. Ma, A. Erkner, R. Gong, S. Yao, J. Taipale, K. Basler, and P. A. Beachy. (2002).Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched. Cell.111, 63-75. 

  3.       C.-H. Chen, D. P. von Kessler, W. Park, B. Wang, Y. Ma, and P. A. Beachy. (1999).Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression. Cell. 98, 305-316. 

  4.       J. A. Porter, S. C. Ekker, W.-J. Park, D. P. von Kessler, K. E. Young, C.-H. Chen, Y. Ma, A. S. Woods, R. J. Cotter, E. V. Koonin, and P. A. Beachy.(1996). Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain. Cell. 86, 21-34. 

  Patent 

  1.       S. Bartz, D. Brown, E. A. Harrington, Y. Ma and U. Philippar. (2011). RNA Interference Mediated Inhibition of MET Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office. Patent No.: WO2011130065 A1, issue date: 10/20/2011.  

  2.       S. Bartz, D. Brown, Y. Ma and J. Semyonov. (2012).RNA Interference Mediated Inhibition of Mitogen-activated Protein Kinase 1 (MAPK1) Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office. Patent No.: WO2012021383 A3, issue date: 2/16/2012. 

  3.       S. Bartz, D. Brown and Y. Ma. (2012).RNA Interference Mediated Inhibition of Isocitrate Dehydrogenase (IDH1) Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office. Patent No.: WO2012170284 A1, issue date: 12/13/2012.